Differential activity of pro-angiogenic CXC chemokines

Novel anti-angiogenic peptides derived from ELR-containing CXC chemokines.

Angiogenesis is tightly regulated by numerous endogenous pro- and anti-angiogenic proteins and peptides. Among these are the CXC chemokines, a set of multifunctional peptides. CXC chemokines containing the ELR motif act as pro-angiogenic agents by regulating both endothelial cell proliferation and migration. Here we show that a set of six 22-24-amino acid peptides derived from the pro-angiogeni...

CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regard...

Lavage Fluid Angiogenic Activity and Bronchoalveolar Chemokines Correlates with Imbalance in the Expression of CXC

CXC chemokines in angiogenesis.

CXC chemokines display pleiotropic effects in immunity, regulating angiogenesis, and mediating organ-specific metastases of cancer. In the context of angiogenesis, CXC chemokines are a unique family of cytokines, known for their ability to behave in a disparate manner in the regulation of angiogenesis. Members that contain the 'ELR' motif are potent promoters of angiogenesis, and mediate their ...

CXC-Chemokines and Thyroid Associated Autoimmunity

Chemokines are a group of peptides of low molecular weight that induce the chemotaxis of different leukocyte subtypes [1]. The major function of chemokines is the induction of leukocyte migration to inflammation sites, but they also play a role in tumoral growth, in angiogenesis and in organ sclerosis [2]. At the present more than 50 chemokines have been described, which can be classified in 4 ...